Rasagiline Dosage
Dosage and administration from FDA labeling • Also known as: Rasagiline
- Dosage Form
- TABLET
- Route
- ORAL
Dosage and Administration
2 DOSAGE AND ADMINISTRATION Monotherapy: Rasagiline tablets 1 mg once daily ( 2.1 ) As adjunct without levodopa: Rasagiline tablets 1 mg once daily ( 2.1 ) As adjunct to levodopa: Rasagiline tablets 0.5 mg once daily. Increase dose to 1 mg daily as needed for sufficient clinical response ( 2.1 ) Patients taking ciprofloxacin or other CYP1A2 inhibitors: Rasagiline tablets 0.5 mg once daily ( 2.2 , 5.4 ) Patients with mild hepatic impairment: Rasagiline tablets 0.5 mg once daily. Rasagiline tablets should not be used in patients with moderate or severe hepatic impairment ( 2.3 , 5.5 ) 2.1 General Dosing Recommendations When rasagiline tablets are prescribed as monotherapy or as adjunct therapy in patients not taking levodopa, patients may start rasagiline at the recommended dose of 1 mg administered orally once daily. In patients taking levodopa, with or without other PD drugs (e.g., dopamine agonist, amantadine, anticholinergics), the recommended initial dose of rasagiline tablets are 0.5 mg once daily. If the patient tolerates the daily 0.5 mg dose, but a sufficient clinical response is not achieved, the dose may be increased to 1 mg once daily. When rasagiline is used in combination with levodopa, a reduction of the levodopa dose may be considered, based upon individual response. The recommended doses of rasagiline should not be exceeded because of risk of hypertension [See Warnings and Precautions (5.1)] . 2.2 Patients Taking Ciprofloxacin or Other CYP1A2 Inhibitors Patients taking concomitant ciprofloxacin or other CYP1A2 inhibitors should not exceed a dose of rasagiline 0.5 mg once daily [see Warnings and Precautions (5.4), Drug Interactions (7.6), and Clinical Pharmacology (12.3)] . 2.3 Patients with Hepatic Impairment Patients with mild hepatic impairment should not exceed a dose of rasagiline 0.5 mg once daily. Rasagiline should not be used in patients with moderate or severe hepatic impairment [see Warnings and Precautions ( 5.5 ), Use in Specific Populations ( 8.6 ), and Clinical Pharmacology ( 12.3 )] .
How Supplied
16 HOW SUPPLIED/STORAGE AND HANDLING Rasagiline Tablets, 0.5 mg White to off-white, uncoated round, flat, beveled tablets, debossed with “RAS” on one side and “0.5” on the other side. Supplied as: NDC 67877-259-30 Bottles of 30 tablets Rasagiline Tablets, 1 mg White to off white, uncoated round, flat, beveled tablets debossed with "RAS" on one side and "1" on other side. Supplied as: NDC 67877-260-30 Bottles of 30 tablets Storage: Store at 25°C (77°F) with excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].
View full Rasagiline information including side effects, interactions, and warnings.
Can I adjust my dosage on my own?
Never change your medication dosage without consulting your healthcare provider. Incorrect dosing can lead to reduced effectiveness or dangerous side effects.