Metoprolol Succinate Er Dosage
Dosage and administration from FDA labeling • Also known as: Metoprolol Succinate Er
- Dosage Form
- TABLET, FILM COATED, EXTENDED RELEASE
- Route
- ORAL
Dosage and Administration
2.1 Hypertension Adults: The usual initial dosage is 25 to 100 mg daily in a single dose. Adjust dosage at weekly (or longer) intervals until optimum blood pressure reduction is achieved. In general, the maximum effect of any given dosage level will be apparent after 1 week of therapy. Dosages above 400 mg per day have not been studied. Pediatric Hypertensive Patients ≥ 6 Years of age: The recommended starting dose of metoprolol succinate extended-release tablet is 1 mg/kg once daily, but the maximum initial dose should not exceed 50 mg once daily. Adjust dosage according to blood pressure response. Doses above 2 mg/kg (or in excess of 200 mg) once daily have not been studied in pediatric patients [ see Use in Specific Populations (8.4) and Clinical Pharmacology (12.3)]. Metoprolol succinate extended-release tablets have not been studied in pediatric patients < 6 years of age [ see Use in Specific Populations (8.4)] . 2.2 Angina Pectoris Individualize the dosage of metoprolol succinate extended-release tablets. The usual initial dosage is 100 mg daily, given in a single dose. Gradually increase the dosage at weekly intervals until optimum clinical response has been obtained or there is a pronounced slowing of the heart rate. Dosages above 400 mg per day have not been studied. If treatment is to be discontinued, reduce the dosage gradually over a period of 1 to 2 weeks [see Warnings and Precautions (5)]. 2.3 Heart Failure Dosage must be individualized and closely monitored during up-titration. Prior to initiation of metoprolol succinate extended-release tablets, stabilize the dose of other heart failure drug therapy. The recommended starting dose of metoprolol succinate extended-release tablet is 25 mg once daily for two weeks in patients with NYHA Class II heart failure and 12.5 mg once daily in patients with more severe heart failure. Double the dose every two weeks to the highest dosage level tolerated by the patient or up to 200 mg of metoprolol succinate extended-release tablets. Initial difficulty with titration should not preclude later attempts to introduce metoprolol succinate extended-release tablets. If patients experience symptomatic bradycardia, reduce the dose of metoprolol succinate extended-release tablets. If transient worsening of heart failure occurs, consider treating with increased doses of diuretics, lowering the dose of metoprolol succinate extended-release tablets or temporarily discontinuing it. The dose of metoprolol succinate extended-release tablets should not be increased until symptoms of worsening heart failure have been stabilized. 2.4 Administration Metoprolol succinate extended-release tablets are scored and can be divided; however, do not crush or chew the whole or half tablet.
How Supplied
Metoprolol succinate extended-release tablets containing metoprolol succinate equivalent to the indicated weight of metoprolol tartrate, USP are available as follows: Metoprolol succinate extended-release tablets USP, 25 mg White to off-white, oval shaped, film coated scored tablets, debossed with I and 25 on either side of the score on one side and score on the other side. Bottles of 90 NDC 72189-652-90 Bottles of 500 NDC 70010-780-05 Bottles of 1000 NDC 70010-780-10 Metoprolol succinate extended-release tablets USP, 50 mg White to off-white, round shaped, film coated scored tablets, debossed with I on one side of the score and 50 on the other side. Bottles of 100 NDC 70010-781-01 Bottles of 500 NDC 70010-781-05 Bottles of 1000 NDC 70010-781-10 Metoprolol succinate extended-release tablets USP, 100 mg White to off-white, round shaped, film coated scored tablets, debossed with I on one side of the score and 100 on the other side. Bottles of 100 NDC 70010-782-01 Bottles of 500 NDC 70010-782-05 Bottles of 1000 NDC 70010-782-10 Metoprolol succinate extended-release tablets USP, 200 mg White to off-white, oval shaped, film coated scored tablets, debossed with I on one side of the score and 200 on the other side. Bottles of 100 NDC 70010-783-01 Bottles of 500 NDC 70010-783-05 Bottles of 1000 NDC 70010-783-10
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Can I adjust my dosage on my own?
Never change your medication dosage without consulting your healthcare provider. Incorrect dosing can lead to reduced effectiveness or dangerous side effects.